NAKAGAMI Yuki Faculty of Data Science, a co-authored paper (joint research with the Department of Gastroenterology and Oncology, Graduate School of Medicine, Yamaguchi University) has been published in an international journal. It was published in an academic journal called ONCOLOGY LETTERS published by SPANDIDOS PUBLICATIONS.

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https://www.spandidos-publications.com/10.3892/ol.2024.14695

<Dissertation Information>　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　

Magazine name: ONCOLOGY LETTERS

Thesis title: Impact of infections after gastrectomy on non-gastric cancer-related deaths "Effect of infectious complications after gastrectomy on non-gastric cancer-related deaths"

Author: CHIYO NAKASHIMA1, MICHIHISA IIDA1, MITSUO NISHIYAMA1, YUSAKU WATANABE1, YOSHITARO SHINDO1, YUKIO TOKUMITSU1, SHINOBU TOMOCHIKA1, YUKI NAKAGAMI1,2, HIDENORI TAKAHASHI1 and HIROAKI NAGANO1

¹Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine

²Department of Data Science, Faculty of Data Science, Shimonoseki City University

<Summary of Research>　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　

Infectious complications (infective complications: IC) have been reported as a major cause of postoperative death in patients with cancer. However, the effects of ICs after gastrectomy on non-gastric cancer-related deaths: NGCDs have not been sufficiently studied so far. In this study, 712 gastric cancer patients who had curative gastroctomy were classified into IC groups and non-IC groups based on postoperative IC occurrences, and analyzed using time-dependent ROC curve analysis taking into account competition risks, estimation of cumulative incidence probability function, Cox regression model based on cause-specific hazard functions, etc. As a result, 112 people developed ICs (Clavien-Dindo Classification Grade ≥II), and in the overall cohort, the five-year cumulative incidence of NGCD was significantly worse than that of non-IC groups. Differences were found in many clinical pathological factors, including patient background, surgical factors, and tumor factors, but no IC development was observed in NGCD risk factors identified in advanced statistical modeling, and age, low prognostic nutrition indicators, low skeletal muscle index, and Charlson coexisting disease index ≥1 were identified as risks. IC groups have many background factors contributing to NGCDs, suggesting that NGCDs may increase regardless of the occurrence of ICs.

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